Latest App Notes & Case Studies
![Discover an Automated Workflow for Precise Metabolite Identification content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/371894/discover-an-automated-workflow-for-precise-metabolite-identification-371894-640x360.jpg?cb=12478151)
App Note / Case Study
Discover an Automated Workflow for Precise Metabolite Identification
Discover an automated processing workflow that utilizes both EAD and CID data for the most confident characterization of pharmaceutical drug metabolites.
![Highly Sensitive Mass Spectrometry Methods for Quantifying PROTACs content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/371273/highly-sensitive-mass-spectrometry-methods-for-quantifying-protacs-371273-640x360.jpg?cb=12478212)
App Note / Case Study
Highly Sensitive Mass Spectrometry Methods for Quantifying PROTACs
Protein-targeting chimeras (PROTACs) have gained significant attention recently due to their high potency in nanomolar drug concentrations and target selectivity. However, low test concentrations in complex matrices present analytical challenges.
![Identifying Metabolites With Confidence content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/371261/identifying-metabolites-with-confidence-371261-640x360.jpg?cb=12446662)
App Note / Case Study
Identifying Metabolites With Confidence
Understanding the effects of in vitro drug metabolism is a key aspect of drug discovery and development. However, researchers must be able to make confident decisions quickly and easily.
![Using Electron Activated Dissociation (EAD) To Characterize Challenging Metabolites content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/371178/using-electron-activated-dissociation-ead-to-characterize-challenging-metabolites-371178-640x360.jpg?cb=12244908)
App Note / Case Study
Using Electron Activated Dissociation (EAD) To Characterize Challenging Metabolites
Glucuronidation is an essential metabolic pathway for drug clearance and its characterization is crucial for optimizing the efficiency and safety of drug candidates.
![Reach New Levels of Metabolite Characterization content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/371175/reach-new-levels-of-metabolite-characterization-371175-640x360.jpg?cb=12203228)
App Note / Case Study
Reach New Levels of Metabolite Characterization
Early ADME studies are used to determine if a drug candidate is prone to metabolic breakdown or oxidation/conjugation. Glucuronide conjugation is difficult to characterize using MS/MS alone, therefore fragmentation is also required to obtain structural information.
![Discover Novel Biomarkers for Drug Discovery and Clinical Diagnostics content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/371134/discover-novel-biomarkers-for-drug-discovery-and-clinical-diagnostics-371134-640x360.jpg?cb=12216191)
App Note / Case Study
Discover Novel Biomarkers for Drug Discovery and Clinical Diagnostics
Developed for performance in human serum and plasma, the SomaScan Assay v4.1 can measure approximately 7,000 unique human protein analytes in small volumes of biological samples.
![Take Your Metabolomics Workflow to the Next Level content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/371059/take-your-metabolomics-workflow-to-the-next-level-371059-640x360.jpg?cb=12206088)
App Note / Case Study
Take Your Metabolomics Workflow to the Next Level
This app note presents a robust workflow that combines automated sample preparation, hydrophilic interaction chromatography and triple quadrupole mass spectrometry that can be applied to plasma and mammalian cell samples.
![Resolve the Complex Cellular Diversity of Your Samples content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/370311/resolve-the-complex-cellular-diversity-of-your-samples-370311-640x360.jpg?cb=12165796)
App Note / Case Study
Resolve the Complex Cellular Diversity of Your Samples
Single-cell RNA sequencing produces a substantial amount of complex data that can be a burden if you don’t have time to become an expert in bioinformatics.
![Application Focus](https://assets.technologynetworks.com/production/dynamic/images/content/369839/enhancing-contract-research-with-automated-liquid-handling-369839-640x360.jpg?cb=12155892)
App Note / Case Study
Enhancing Contract Research with Automated Liquid Handling
This application focus summarizes the key points from a webinar focused on the benefits and applications of automated liquid handling.
![Simple and Fast Tracking of Drug–Antibody Ratio Distribution content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/369036/simple-and-fast-tracking-of-drug-antibody-ratio-distribution-369036-640x360.jpg?cb=12145708)
App Note / Case Study
Simple and Fast Tracking of Drug–Antibody Ratio Distribution
Antibody drug conjugates (ADCs) are biotherapeutics, composed of small molecule drugs conjugated to an antibody scaffold, that have very complex molecular structures.
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