Latest App Notes & Case Studies
![Consistency is Key to Further Drug Discovery Research content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/368653/consistency-is-key-to-further-drug-discovery-research-368653-640x360.jpg?cb=12082175)
App Note / Case Study
Consistency is Key to Further Drug Discovery Research
Energy metabolism plays a central role in a wide variety of cellular and physiological processes. Therefore, a deep understanding of how disruption to energy metabolism impacts cells can help in therapeutic drug discovery and development.
![Recombinant Protein Expression Using a Baculovirus–Insect Cell System content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/368559/recombinant-protein-expression-using-a-baculovirus-insect-cell-system-368559-640x360.jpg?cb=12149959)
App Note / Case Study
Recombinant Protein Expression Using a Baculovirus–Insect Cell System
Download this app note to discover a method of recombinant protein expression that enables correct protein folding and post translational modification, is suitable for high-density cell culture, and can produce both secreted and intracellular proteins of various species.
![Developing Next-Generation <i>In Vitro</i> Phenotypic Assays for Huntington’s Disease content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/368157/developing-next-generation-in-vitro-phenotypic-assays-for-huntingtons-disease-368157-640x360.jpg?cb=12059456)
App Note / Case Study
Developing Next-Generation In Vitro Phenotypic Assays for Huntington’s Disease
There is currently no effective cure or treatment to slow down or stop the progression of Huntington's disease (HD). One reason for this is the lack of accurate and easy-to-use HD models.
![RatPlasma](https://assets.technologynetworks.com/production/dynamic/images/content/367770/sensitive-analysis-of-a-protac-degrader-in-rat-plasma-367770-640x360.jpg?cb=12485645)
App Note / Case Study
Sensitive Analysis of a PROTAC Degrader in Rat Plasma
Proteolysis targeting chimera (PROTAC) degraders are used to treat drug-resistant targets via targeted protein degradation.
![Rare Cell Discovery With a High-Plex Imaging Platform content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/367520/rare-cell-discovery-with-a-high-plex-imaging-platform-367520-640x360.jpg?cb=12163122)
App Note / Case Study
Rare Cell Discovery With a High-Plex Imaging Platform
Rare cells play pivotal roles in disease initiation, maintenance and progression. Yet, identifying these cells remains a difficult task for low-plex technologies, as it is not always clear a priori which biomarkers distinguish rare phenotypes from the remaining population.
![Cell Painting High-Content Screening Assay content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/367516/cell-painting-high-content-screening-assay-367516-640x360.jpg?cb=12023726)
App Note / Case Study
Cell Painting High-Content Screening Assay
In drug screening, conventional high-throughput applications evaluate only a few measurements and have limited breadth to detect diverse phenotypic changes caused by compound exposure.
![Effortlessly Analyze Pyruvate Kinase Inhibitors content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/366971/effortlessly-analyze-pyruvate-kinase-inhibitors-366971-640x360.jpg?cb=12001818)
App Note / Case Study
Effortlessly Analyze Pyruvate Kinase Inhibitors
Pyruvate kinase is an enzyme involved in energy-supplying glycolysis and ATP synthesis, thus is pivotal for the eucaryotic energy metabolism. In addition, overexpression of pyruvate kinase is believed to play a role in cancer.
![An LC-MS/MS Toxicology Workflow for Screening Drugs content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/366122/an-lc-msms-toxicology-workflow-for-screening-drugs-366122-640x360.jpg?cb=11963067)
App Note / Case Study
An LC-MS/MS Toxicology Workflow for Screening Drugs
One of the major challenges faced by most toxicology laboratories is analyzing hundreds of drugs of abuse in biological samples. This is further complicated by the constantly increasing emergence in the volume of designer and illicit drugs.
![A Highly Robust and Sensitive Workflow for Quantifying RTP004 in Rat Serum content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/365813/a-highly-robust-and-sensitive-workflow-for-quantifying-rtp004-in-rat-serum-365813-640x360.jpg?cb=12341572)
App Note / Case Study
A Highly Robust and Sensitive Workflow for Quantifying RTP004 in Rat Serum
RTP004 is a proprietary peptide used by Revance Therapeutics as a novel excipient in DaxibotulinumtoxinA for injection. Due to its high molecular weight, high isoelectric point and strong non-specific binding property, the sample preparation and LC-MS method development for this peptide is very challenging.
![Microflow Chromatography: A Key to More Sensitive Metabolite Identification content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/365811/microflow-chromatography-a-key-to-more-sensitive-metabolite-identification-365811-640x360.jpg?cb=11950000)
App Note / Case Study
Microflow Chromatography: A Key to More Sensitive Metabolite Identification
In early-stage pharmaceutical research, knowledge of a compound’s metabolism can assist in the identification of structural liabilities that can contribute to non-optimal pharmacokinetics, potentially toxic breakdown products or the potential for drug-drug interactions.
Advertisement