Latest App Notes & Case Studies
![Preclinical Quantification of Trastuzumab in Rat Plasma content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/365809/pre-clinical-quantification-of-trastuzumab-in-rat-plasma-365809-640x360.jpg?cb=12024829)
App Note / Case Study
Preclinical Quantification of Trastuzumab in Rat Plasma
In quantifying therapeutic peptides and proteins in biological matrices, traditional ELISA-only based techniques can suffer from high variability, narrow dynamic range, problems with selectivity and typically cannot use internal standards.
![Achieve Next Level Sensitivity for the Evolution of Routine Bioanalysis content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/365807/achieve-next-level-sensitivity-for-the-evolution-of-routine-bioanalysis-365807-640x360.jpg?cb=12317601)
App Note / Case Study
Achieve Next Level Sensitivity for the Evolution of Routine Bioanalysis
Sample preparation and alternative chromatography techniques are often used to meet the sensitivity needs required in routine bioanalytical assays, but these methods can be time consuming.
![Cyclic Peptide Quantitation in Human Plasma content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/365804/cyclic-peptide-quantitation-in-human-plasma-365804-640x360.jpg?cb=12341481)
App Note / Case Study
Cyclic Peptide Quantitation in Human Plasma
In biotherapeutic development, decreased drug doses and limited sample volumes require higher quantification sensitivity, while the complexity of biological matrices calls for the need of assay selectivity improvement.
![Bioanalysis of Small Molecule Pharmaceuticals Using Accurate Mass Spectrometry content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/365802/bioanalysis-of-small-molecule-pharmaceuticals-using-accurate-mass-spectrometry-365802-640x360.jpg?cb=12341653)
App Note / Case Study
Bioanalysis of Small Molecule Pharmaceuticals Using Accurate Mass Spectrometry
Demands for improved sensitivity in routine bioanalytical assays continue to increase as drug discovery and development programs focus on more efficacious, lower dosage compounds. Pharma development scientists supporting this work therefore require highly sensitive and selective bioanalytical methods for quantification.
![Early Screening of Pancreatic Cancer Immunotherapy Target Candidates content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/365414/early-screening-of-pancreatic-cancer-immunotherapy-target-candidates-365414-640x360.jpg?cb=11929976)
App Note / Case Study
Early Screening of Pancreatic Cancer Immunotherapy Target Candidates
It has proven difficult to accurately identify the biological targets of cancer, which are necessary for the development of successful therapeutics including novel immunotherapies, such as those based on chimeric antigen receptor (CAR) T cells.
![Accelerating Target Validation for Therapeutics With Engineered Cell Libraries content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/365490/accelerating-target-validation-for-therapeutics-with-engineered-cell-libraries-365490-640x360.jpg?cb=11932492)
App Note / Case Study
Accelerating Target Validation for Therapeutics With Engineered Cell Libraries
One approach to develop drugs for infectious diseases involves a comprehensive understanding of human-pathogen protein interactions, as targeting host proteins helps reduce the possibility of drug resistance by creating a more significant evolutionary barrier for the virus.
![Automated Protein Sample Preparation in Regulated Environments content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/365033/automated-protein-sample-preparation-in-regulated-environments-365033-640x360.jpg?cb=11911174)
App Note / Case Study
Automated Protein Sample Preparation in Regulated Environments
Download this application focus to learn more about the benefits of automated sample preparation for drug development.
![Detection and Characterization of Mitochondrial Toxicity content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/364455/detection-and-characterization-of-mitochondrial-toxicity-364455-640x360.jpg?cb=11892043)
App Note / Case Study
Detection and Characterization of Mitochondrial Toxicity
A Customized XF Workflow for Detection and Characterization of Mitochondrial Toxicity
Many different classes of drugs can cause drug-induced mitochondrial toxicity, which may result in brain, cardiac, liver, muscle and/or kidney injury.
Many different classes of drugs can cause drug-induced mitochondrial toxicity, which may result in brain, cardiac, liver, muscle and/or kidney injury.
![Kinetic Curvature: Assessment of Small Molecule Kinetics and Affinity content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/364416/kinetic-curvature-assessment-of-small-molecule-kinetics-and-affinity-364416-640x360.jpg?cb=11882385)
App Note / Case Study
Kinetic Curvature: Assessment of Small Molecule Kinetics and Affinity
Surface plasmon resonance (SPR) is a core technology used in many pharma and biotechnology settings for this purpose, however traditional initial SPR screening of weak affinity compounds using a single fixed concentration injection can present numerous challenges.
![CRISPR Engineered Cells Enable Variant Disease Modeling content piece image](https://assets.technologynetworks.com/production/dynamic/images/content/364414/crispr-engineered-cells-enable-variant-disease-modeling-364414-640x360.jpg?cb=11882320)
App Note / Case Study
CRISPR Engineered Cells Enable Variant Disease Modeling
Comprehensive disease modeling can be challenging for many labs due to variations in reagents, cell culture conditions, technical inconsistencies across protocols and experiments and bandwidth limitations.
Advertisement